Comprehensive Health Risk Questionnaire
More than just a medical history, this in-depth questionnaire uncovers the layers of your experiences, environment, and emotions that have shaped your current state of well-being.
Your Journey to Optimal Health Starts Here
At Apicella Health, we understand that every individual is unique, which is why The Precision Health Review offers a personalized approach to uncovering the root causes of your health concerns. Led by Dr. Vincent Apicella, this comprehensive program combines advanced diagnostics with actionable strategies to empower you to take control of your well-being.
Low energy production, potential oxidative stress.
CoQ10
µg/mL
May suggest hormonal imbalance or low T.
Testosterone
ng/dL
May reflect growth hormone deficiency.
IGF-1
ng/mL
Strong marker for rheumatoid arthritis.
Anti-CCP3 IgG and IgA
U
High inflammation, possible heart disease risk.
hs-CRP
mg/L
May indicate thyroid hormone conversion issues.
Reverse T3
ng/dL
Genetic cholesterol risk factor for heart disease.
Lp(a)
mg/dL
Elevated cardiovascular and stroke risk.
Homocysteine
µmol/L
Marker of vascular inflammation and plaque risk.
MPO
pmol/L
Possible insulin resistance or early diabetes.
Fasting Insulin
µU/mL
Low levels linked to metabolic syndrome.
Adiponectin
µg/mL
May suggest leptin resistance or obesity risk.
Leptin
ng/mL
100+ Biomarkers
Our expert-curated panel of over 100 biomarkers gives you an unmatched view into your body’s inner workings—from hormones and heart health to nutrition and inflammation. Designed for proactive health seekers, this test empowers you to track changes, uncover risks early, and optimize every aspect of your well-being—all backed by science, not guesswork.
Evaluates oxygen-carrying capacity and screens for anemia or other blood disorders.
Oxygen-carrying molecule in red blood cells.
Expressed as a percentage of the volume of RBCs in a known volume of centrifuged blood.
One of the RBC indices to differentiate anemia. Can help determine the type of anemia.
Average weight of hemoglobin per red blood cell. Can help determine the cause of anemia.
Average concentration of hemoglobin in RBC. Can help monitor anemia therapy.
Measures the variation in size of red blood cells, used to diagnose and monitor various types of anemia and other blood disorders.
This test measures the variation in the size of your red blood cells. A higher RDW can suggest conditions like anemia or nutrient deficiencies (such as iron, B12, or folate).
Measures blood clotting ability and screens for bleeding disorders or thrombocytopenia.
WBCs are used to combat bacterial or pyrogenic infections. The body’s most numerous and significant WBC in the body’s reaction to inflammation.
Made in the bone marrow, and are used by the body to destroy and get rid of toxic byproducts of protein metabolism.
The body’s second line of defense against infection. They are phagocytic cells that remove dead cells, microorganisms, and particulate matter from the circulating blood.
Type of white blood cell involved in allergic reactions and parasitic infections; elevated levels may indicate allergies, asthma, or parasitic infections.
Type of white blood cell involved in allergic reactions and inflammatory responses; elevated levels may indicate allergies or certain inflammatory conditions.
Refers to immature forms of white blood cells (neutrophils, eosinophils, and basophils); elevated levels may indicate infection, inflammation, or bone marrow disorders.
Measures the number of lymphocytes, which are white blood cells involved in immune responses; alterations may indicate viral infections, immune system disorders, or certain cancers.
Measures the number of monocytes, a type of white blood cell involved in immune defense and inflammation; elevated levels may indicate chronic infections, autoimmune diseases, or inflammatory conditions.
Measures the number of eosinophils, a type of white blood cell involved in allergic reactions, parasitic infections, and certain inflammatory conditions.
Measures the number of basophils, a type of white blood cell involved in allergic reactions and inflammation, particularly in response to parasitic infections and allergic conditions.
Measures the number of immature forms of granulocytes (including neutrophils, eosinophils, and basophils), which may increase in response to infections, inflammation, or bone marrow disorders.
Measures the average size of platelets and may help diagnose certain platelet disorders or assess the risk of cardiovascular events.
NRBCs are immature RBC precursors that are usually not present in the circulation of healthy adults. This marker measures the number of RBCs with nuclei present in the bloodstream, which typically indicates increased erythropoiesis (red blood cell production) in response to various conditions such as hypoxia, bone marrow disorders, or certain infections.
Represents the percentage of nucleated red blood cells in the total red blood cell population, providing insight into the degree of erythropoiesis occurring in the body.
Measures the number of neutrophils, the most abundant type of white blood cell, involved in fighting bacterial infections; elevated levels may indicate bacterial infections or inflammation.
Protein that stores iron in cells, reflecting the body's iron stores; used to assess iron status and diagnose iron deficiency or iron overload disorders.
70% of iron in the body is in the form of hemoglobin. The remaining 30% is found in the storage form in the liver, spleen, and bone marrow.
Unsaturated iron-binding capacity (UIBC) determines the reserve capacity of transferrin, i.e., the portion not yet saturated with iron. UIBC is used to calculate TIBC. TIBC = UIBC + iron.
Primary iron-binding protein. This marker approximates the amount of transferrin available to bind to iron.
Protein that carries most of the iron in the blood.
A value that is a better index of iron saturation than transferrin levels.
Folate (Vitamin B9) is the naturally occurring form found in foods; folic acid is the supplement/ synthetic form of B9.
Vitamin D, 25-OH, is the inactive precursor to 1,25-OH-D3, the active form of vitamin D (calcitriol).
Vitamin B12 (cobalamin) plays an essential role in red blood cell formation, cell metabolism, nerve function, and the production of DNA, the molecules inside cells that carry genetic information.
Magnesium is a vital mineral that helps with muscle and nerve function, blood sugar control, blood pressure regulation, and making protein, bone, and DNA. Low levels may cause fatigue, cramps, or irregular heartbeat, while healthy levels support overall wellness.
CoQ10 (Coenzyme Q10) is a powerful antioxidant that helps produce energy in your cells, especially in the heart and muscles. Healthy levels support heart health, brain function, and energy production. Low levels may be linked to fatigue, muscle weakness, or certain chronic conditions.
This panel measures the balance of omega-3 and omega-6 fatty acids in your blood.
Omega-3s (like EPA and DHA) help reduce inflammation, support heart, brain, and joint health.
Omega-6s are also essential but can promote inflammation when too high.
A healthy omega-3 to omega-6 ratio is important for reducing the risk of chronic diseases. An imbalance may suggest the need for dietary adjustments.
Omega-3s (like EPA and DHA) help reduce inflammation, support heart, brain, and joint health.
Omega-6s are also essential but can promote inflammation when too high.
A healthy omega-3 to omega-6 ratio is important for reducing the risk of chronic diseases. An imbalance may suggest the need for dietary adjustments.
Commonly known as E2 or 17β-Estradiol, it is the predominant and most biologically active estrogen in circulation in males and females.
In females, FSH stimulates follicles on the ovary to grow and mature in preparation for ovulation. As the follicles increase in size, they begin to release estrogen and a low level of progesterone into your blood.
Dehydroepiandrosterone sulfate (DHEAS) is a male sex hormone found in both men and women. It plays a vital role in making the male sex hormone testosterone and the female sex hormone estrogen and is involved in the development of male sexual characteristics at puberty.
LH plays a role in sexual development in children and fertility in adults. In women, LH triggers the release of an egg from the ovary and is highest before ovulation. In men, LH causes testicles to make the testosterone needed to produce sperm. Typically, levels in men do not change much. In children, LH levels are low, but in girls, LH signals ovaries to make estrogen and is involved in the growth of breasts, body hair, and the start of menstruation. In boys, LH signals testicles to produce testosterone involved in facial and body hair development, changes in one’s voice, and sperm production.
SHBG helps control the amount of sex hormones that are actively working in the body. When the SHBG protein binds to sex hormones, they are bound and unavailable for tissues to use. Tissues can only use sex hormones that are "free," which means they aren't attached to proteins, such as SHBG.
Known as “the stress hormone,” cortisol plays a significant role in maintaining glucose and protein homeostasis, mediating the stress and immune response, and suppressing inflammation.
Measures free testosterone and testosterone that are attached to proteins.
It measures only the "active" form of testosterone, which is not attached to proteins.
Progesterone is the precursor to critical steroid hormones such as aldosterone, cortisol, testosterone, and estradiol. It also has essential cardiovascular, renal, and musculoskeletal functions.
Parathyroid Hormone (PTH) is released from the parathyroid glands to control calcium levels in your blood. It also controls phosphorus and vitamin D levels.
Hormone responsible for lactation, certain breast tissue development, and milk production.
DHT plays a vital role in the sexual development of males. During embryonic life, DHT is involved primarily in the sexual differentiation of organs. Through adolescence and adulthood, DHT promotes prostate growth, sebaceous gland activity, male pattern baldness, and body, facial, and pubic hair growth. This hormone, however, does not seem to play any significant role in normal female physiology.
A precursor to various steroid hormones, including cortisol, progesterone, estrogen, and testosterone. Sometimes measured to assess adrenal function and hormonal balance.
Insulin-like Growth Factor 1 is a hormone primarily produced in the liver in response to growth hormone stimulation, playing a role in cell growth, development, and metabolism; levels may be altered in growth disorders, acromegaly, or metabolic.
This test measures the total amount of PSA in the blood, a protein produced by the prostate gland. Elevated levels may indicate prostate conditions such as enlargement, inflammation, or prostate cancer. It is commonly used as a screening tool for early detection of prostate cancer.
Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation of the joints. The presence of RF IgM suggests that the immune system is producing antibodies that target the body's own tissues, leading to joint inflammation and damage.
Rheumatoid factor (RF) is an autoantibody that can be associated with various autoimmune diseases, particularly rheumatoid arthritis (RA). RF IgM refers to the immunoglobulin M class of rheumatoid factor.
Anti-cyclic citrullinated peptide (anti-CCP) antibodies are autoantibodies associated with RA.
High sensitivity C-reactive protein measures C-reactive protein levels, a marker of systemic inflammation and cardiovascular risk.
Antinuclear Antibody (ANA) by IFA is a test that refers to ANA detection by indirect fluorescent antibody (IFA) assay to detect the presence of ANA in blood.
T3 is the most active thyroid hormone and is primarily produced from the conversion of thyroxine (T4) in the peripheral tissue. Total T3 measures the T3 that is both attached to proteins and floating free in the blood.
Total T4 measures the T4 that is both attached to proteins and floating free in the blood.
Free T3 measures only the T3 that is floating free in the blood.
Free T4 measures only the T4 that is floating free in the blood.
It indicates thyroid function and is often included in assessing thyroid health and screening for thyroid disorders.
Thyroid antibodies arise when the immune system erroneously identifies components of the thyroid gland or proteins as threats. This autoimmune reaction, characterized by the immune system mistakenly attacking body tissues, can result in persistent thyroid inflammation, tissue injury, and/or interference with thyroid function.
Reverse Triiodothyronine (reverse T3, rT3) is a metabolically inactive form of thyroid hormone and is a product of T4 degradation.
Measures antibodies against thyroglobulin and is used to diagnose autoimmune thyroid disease (AITD).
An electrolyte essential for maintaining fluid balance, nerve function, and muscle contraction.
Electrolytes crucial for nerve and muscle function, including heart rhythm regulation.
A general marker for acidity that tends towards an inverse relationship with CO2 levels and a positive relationship with sodium levels
Essential for maintaining blood pH balance.
Reflects the level of glucose filtered and reabsorbed by the kidneys, providing insight into kidney function.
Measures the concentration of urea nitrogen in the blood, serving as an indicator of kidney function and hydration status.
Indicates the level of creatinine, a waste product of muscle metabolism, in the blood; used to assess kidney function.
An estimate of the kidney's filtration rate, calculated based on serum creatinine levels, age, sex, and other factors, is a key indicator of kidney function.
Similar to eGFR but adjusted for individuals of African American descent. Please note the National Kidney Foundation (NKF) has stated that the U.S. now mandates all transplant hospitals adopt a new race-free eGFR equation.
Provides additional information about kidney function and hydration status.
Essential for bone health, muscle function, nerve transmission, and various biochemical processes in the body.
The most abundant protein in the blood plasma that plays a critical role in maintaining oncotic pressure, transporting various substances, and regulating fluid balance.
ALT (Alanine Aminotransferase) is an enzyme primarily found in the liver.
Aspartate Aminotransferase is an enzyme found in various tissues, including the liver, heart, muscles, and kidneys.
Measures the total amount of bilirubin in the blood, a waste product from the breakdown of red blood cells.
Measures the total amount of protein in the blood, including albumin and globulins.
Enzymes found in various tissues, including the liver, bones, kidneys, and intestines.
Measures the concentration of solutes in the blood plasma, reflecting the body's hydration status and electrolyte balance.
Represents the total amount of cholesterol in the blood, including both LDL (low-density lipoprotein) and HDL (high-density lipoprotein) cholesterol.
Estimates LDL cholesterol based on the Friedewald formula (FF): total cholesterol (TC) minus HDL cholesterol minus triglycerides (TGs)/5 in mg/dl. Used to assess cardiovascular risk. The FF is not valid for patients with TGs >400 and those with type 3 dyslipoproteinemia.
Measures the level of HDL cholesterol, often referred to as "good" cholesterol due to its protective effects against cardiovascular disease.
This ratio is calculated by dividing the total cholesterol by the HDL level. An ideal ratio is 5:1, with an even more favorable ratio at 3.5:1.
They function as carriers for fatty acids, provide a source of energy, insulate and protect organs, and help transport fat-soluble vitamins.
Directly measures LDL cholesterol level rather than using an equation to estimate LDL levels.
Apolipoprotein A1, the main protein component of HDL cholesterol; higher levels are associated with decreased cardiovascular risk.
Apolipoprotein B, the main protein component of LDL cholesterol; higher levels are associated with increased cardiovascular risk.
The ratio of Apo B to Apo A-1 that is considered a sensitive marker of atherogenic risk.
Small Dense LDL is a subtype of LDL cholesterol associated with increased cardiovascular risk due to its ability to penetrate arterial walls more easily.
Genetic variation of LDL cholesterol associated with increased risk of cardiovascular disease and atherosclerosis.
Measures lipoprotein-associated phospholipase A2, a marker of vascular inflammation and atherosclerosis.
Amino acid associated with an increased risk of cardiovascular disease when elevated; may indicate deficiencies in B vitamins or genetic factors.
Oxidized LDL is LDL cholesterol that has undergone oxidation, contributing to atherosclerosis and cardiovascular disease.
Myeloperoxidase is an enzyme released by white blood cells and is associated with oxidative stress, inflammation, and increased cardiovascular risk. It is abundantly expressed in immune cells (neutrophils, lymphocytes, monocytes, macrophages) and other body cells.
Hs-CRP measures levels of C-reactive protein, a marker of systemic inflammation and cardiovascular risk.
Uric acid is a waste product created when the body breaks down purines. This marker determines how well the body produces and removes uric acid.
Measures the concentration of glucose in the blood, used for diagnosing and monitoring diabetes mellitus and assessing glycemic control.
Reflects average blood glucose levels over the past three months, providing a long-term indicator of glycemic control.
Hormone produced by the pancreas that regulates blood glucose levels by promoting glucose uptake by cells.
Reflects the percentage of serum proteins, e.g., fructosamine and glycated albumin that are glycated (bound to glucose molecules) and provides an alternative marker for assessing glycemic control.
Adipokine hormone secreted by adipose tissue, plays a role in regulating glucose levels, fatty acid oxidation, and inflammation.
Hormone produced by adipose tissue; play a key role in regulating energy balance, appetite, and metabolism.
The Ultimate Diagnostic Approach
Imagine a future where you have complete clarity about your health. The Precision Health Review turns that vision into reality with:
Comprehensive Lab Assessment
valuating over 100 advanced metabolic biomarkers, this assessment dives deep into your cellular function. It identifies existing disruptions and provides prognostic indicators of potential future problems before symptoms manifest.
Personalized Lab Review Session
One-on-one with Dr. Apicella, this session combines insights from the questionnaire and lab work to deliver a holistic understanding of your health.
Customized Treatment Plan
Dr. Apicella provides tailored recommendations and strategies to guide you on your journey with accurate and thorough information about your current state of wellness.
PART 1
Health Insights & Biomarker Testing
Are you seeking clarity in your health journey?
Unlock the power of your health data. The first step of The Precision Health Review focuses on cutting-edge biomarker testing, offering a deep dive into your body’s current state. These insights reveal:
- Key indicators of your overall health and wellness.
- Potential risks for chronic conditions.
- Opportunities to optimize your performance and vitality.
Using state-of-the-art tools and methodologies, we deliver a clear and detailed picture of your health’s foundation.
PART 2
Comprehensive Metabolic Assessment & Solutions
Whether you’re seeking answers to unresolved health challenges or aiming to optimize your well-being, Part 2 of The Precision Health Review is your gateway to clarity and actionable solutions. With Dr. Apicella’s expert guidance, we:
- Conduct a comprehensive metabolic assessment to identify underlying imbalances.
- Develop a personalized strategy tailored to your unique needs and goals.
- Address issues that traditional medicine may have overlooked.
Think of this as your "medical crystal ball" – providing insights into where you are now and charting a path to your healthiest future.
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Precision Health Review Programs
All Aspects of The Health Collective Membership 
Comprehensive Health Risk Assessment
Advanced Lab Assessments (100+ Biomarkers)
Personalized Lab Review Session with Dr. A
Customized Treatment Plan
Uncover Answers with Expert Precision
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